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Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease
Huntington’s disease is an autosomal dominant disease associated with a mutation in the gene encoding huntingtin (Htt) leading to expanded polyglutamine repeats of mutant Htt (mHtt) that elicit oxidative stress, neurotoxicity, and motor and behavioural changes(1). Huntington’s disease is characteriz...
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| Vydáno v: | Nature |
|---|---|
| Hlavní autoři: | , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2014
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4349202/ https://ncbi.nlm.nih.gov/pubmed/24670645 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13136 |
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