Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington’s disease

Huntington’s disease is an autosomal dominant disease associated with a mutation in the gene encoding huntingtin (Htt) leading to expanded polyglutamine repeats of mutant Htt (mHtt) that elicit oxidative stress, neurotoxicity, and motor and behavioural changes(1). Huntington’s disease is characteriz...

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Udgivet i:Nature
Main Authors: Paul, Bindu D., Sbodio, Juan I., Xu, Risheng, Vandiver, M. Scott, Cha, Jiyoung Y., Snowman, Adele M., Snyder, Solomon H.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349202/
https://ncbi.nlm.nih.gov/pubmed/24670645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature13136
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