Altered trafficking and stability of polycystins underlie polycystic kidney disease

The most severe form of autosomal dominant polycystic kidney disease occurs in patients with mutations in the gene (PKD1) encoding polycystin-1 (PC1). PC1 is a complex polytopic membrane protein expressed in cilia that undergoes autoproteolytic cleavage at a G protein–coupled receptor proteolytic si...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Clin Invest
Päätekijät: Cai, Yiqiang, Fedeles, Sorin V., Dong, Ke, Anyatonwu, Georgia, Onoe, Tamehito, Mitobe, Michihiro, Gao, Jian-Dong, Okuhara, Dayne, Tian, Xin, Gallagher, Anna-Rachel, Tang, Zhangui, Xie, Xiaoli, Lalioti, Maria D., Lee, Ann-Hwee, Ehrlich, Barbara E., Somlo, Stefan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Clinical Investigation 2014
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348948/
https://ncbi.nlm.nih.gov/pubmed/25365220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67273
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