Altered trafficking and stability of polycystins underlie polycystic kidney disease

The most severe form of autosomal dominant polycystic kidney disease occurs in patients with mutations in the gene (PKD1) encoding polycystin-1 (PC1). PC1 is a complex polytopic membrane protein expressed in cilia that undergoes autoproteolytic cleavage at a G protein–coupled receptor proteolytic si...

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Xehetasun bibliografikoak
Argitaratua izan da:J Clin Invest
Egile Nagusiak: Cai, Yiqiang, Fedeles, Sorin V., Dong, Ke, Anyatonwu, Georgia, Onoe, Tamehito, Mitobe, Michihiro, Gao, Jian-Dong, Okuhara, Dayne, Tian, Xin, Gallagher, Anna-Rachel, Tang, Zhangui, Xie, Xiaoli, Lalioti, Maria D., Lee, Ann-Hwee, Ehrlich, Barbara E., Somlo, Stefan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2014
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348948/
https://ncbi.nlm.nih.gov/pubmed/25365220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67273
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