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Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2

Mutations in polycystin-2 (PC2) cause autosomal dominant polycystic kidney disease. A function for PC2 in the heart has not been described. Here, we show that PC2 coimmunoprecipitates with the cardiac ryanodine receptor (RyR2) from mouse heart. Biochemical assays showed that the N terminus of PC2 bi...

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Détails bibliographiques
Auteurs principaux: Anyatonwu, Georgia I., Estrada, Manuel, Tian, Xin, Somlo, Stefan, Ehrlich, Barbara E.
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2007
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC1851053/
https://ncbi.nlm.nih.gov/pubmed/17404231
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0610324104
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