Altered trafficking and stability of polycystins underlie polycystic kidney disease

The most severe form of autosomal dominant polycystic kidney disease occurs in patients with mutations in the gene (PKD1) encoding polycystin-1 (PC1). PC1 is a complex polytopic membrane protein expressed in cilia that undergoes autoproteolytic cleavage at a G protein–coupled receptor proteolytic si...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Cai, Yiqiang, Fedeles, Sorin V., Dong, Ke, Anyatonwu, Georgia, Onoe, Tamehito, Mitobe, Michihiro, Gao, Jian-Dong, Okuhara, Dayne, Tian, Xin, Gallagher, Anna-Rachel, Tang, Zhangui, Xie, Xiaoli, Lalioti, Maria D., Lee, Ann-Hwee, Ehrlich, Barbara E., Somlo, Stefan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348948/
https://ncbi.nlm.nih.gov/pubmed/25365220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67273
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