Altered trafficking and stability of polycystins underlie polycystic kidney disease

The most severe form of autosomal dominant polycystic kidney disease occurs in patients with mutations in the gene (PKD1) encoding polycystin-1 (PC1). PC1 is a complex polytopic membrane protein expressed in cilia that undergoes autoproteolytic cleavage at a G protein–coupled receptor proteolytic si...

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Gepubliceerd in:J Clin Invest
Hoofdauteurs: Cai, Yiqiang, Fedeles, Sorin V., Dong, Ke, Anyatonwu, Georgia, Onoe, Tamehito, Mitobe, Michihiro, Gao, Jian-Dong, Okuhara, Dayne, Tian, Xin, Gallagher, Anna-Rachel, Tang, Zhangui, Xie, Xiaoli, Lalioti, Maria D., Lee, Ann-Hwee, Ehrlich, Barbara E., Somlo, Stefan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2014
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348948/
https://ncbi.nlm.nih.gov/pubmed/25365220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI67273
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