DNA Methyl Transferase 1 Reduces Expression of SRD5A2 in the Aging Adult Prostate

5-α Reductase type 2 (SRD5A2) is a critical enzyme for prostatic development and growth. Inhibition of SRD5A2 by finasteride is used commonly for the management of urinary obstruction caused by benign prostatic hyperplasia. Contrary to common belief, we have found that expression of SRD5A2 is variab...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Pathol
Hauptverfasser: Ge, Rongbin, Wang, Zongwei, Bechis, Seth K., Otsetov, Alexander G., Hua, Shengyu, Wu, Shulin, Wu, Chin-Lee, Tabatabaei, Shahin, Olumi, Aria F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2015
Schlagworte:
Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4348471/
https://ncbi.nlm.nih.gov/pubmed/25700986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.11.020
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