Age and Obesity Promote Methylation and Suppression of 5-Alpha Reductase 2–Implications for Personalized Therapy in Benign Prostatic Hyperplasia

PURPOSE: 5α reductase inhibitors (5ARIs) are a main modality of treatment for men suffering from symptomatic benign prostatic hyperplasia (BPH). Over 30% of men do not respond to the therapeutic effects of 5ARIs. We have found that 1/3 of adult prostate samples do not express 5AR2 secondary to epige...

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Detalhes bibliográficos
Publicado no:J Urol
Main Authors: Bechis, Seth K., Otsetov, Alexander G., Ge, Rongbin, Wang, Zongwei, Vangel, Mark G., Wu, Chin-Lee, Tabatabaei, Shahin, Olumi, Aria F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4761873/
https://ncbi.nlm.nih.gov/pubmed/25916673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.juro.2015.04.079
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