Mitochondrial Malic Enzyme 3 Is Important for Insulin Secretion in Pancreatic β-Cells

Pancreatic β-cells with severely knocked down cytosolic malic enzyme (ME1) and mitochondrial NAD(P) malic enzyme (ME2) show normal insulin secretion. The mitochondrial NADP malic enzyme (ME3) is very low in pancreatic β-cells, and ME3 was previously thought unimportant for insulin secretion. Using s...

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Detaylı Bibliyografya
Yayımlandı:Mol Endocrinol
Asıl Yazarlar: Hasan, Noaman M., Longacre, Melissa J., Stoker, Scott W., Kendrick, Mindy A., MacDonald, Michael J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Endocrine Society 2015
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4347290/
https://ncbi.nlm.nih.gov/pubmed/25594249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2014-1249
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