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Studies With Leucine, β-Hydroxybutyrate and ATP Citrate Lyase Deficient Beta Cells Support the Acetoacetate Pathway of Insulin Secretion

We hypothesized that contrasting leucine with its non-metabolizable analog 2-aminobicyclo[2,2,1]heptane-2-carboxylic acid (BCH) might provide new information about metabolic pathways involved in insulin secretion. Both compounds stimulate insulin secretion by allosterically activating glutamate dehy...

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Detalhes bibliográficos
Main Authors: MacDonald, Michael J., Hasan, Noaman M., Longacre, Melissa J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2756157/
https://ncbi.nlm.nih.gov/pubmed/18439432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagen.2008.03.017
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