Differences between Human and Rodent Pancreatic Islets: LOW PYRUVATE CARBOXYLASE, ATP CITRATE LYASE, AND PYRUVATE CARBOXYLATION AND HIGH GLUCOSE-STIMULATED ACETOACETATE IN HUMAN PANCREATIC ISLETS

Anaplerosis, the net synthesis in mitochondria of citric acid cycle intermediates, and cataplerosis, their export to the cytosol, have been shown to be important for insulin secretion in rodent beta cells. However, human islets may be different. We observed that the enzyme activity, protein level, a...

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Detalhes bibliográficos
Main Authors: MacDonald, Michael J., Longacre, Melissa J., Stoker, Scott W., Kendrick, Mindy, Thonpho, Ansaya, Brown, Laura J., Hasan, Noaman M., Jitrapakdee, Sarawut, Fukao, Toshiyuki, Hanson, Matthew S., Fernandez, Luis A., Odorico, Jon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099655/
https://ncbi.nlm.nih.gov/pubmed/21454710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241182
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