Differences between Human and Rodent Pancreatic Islets: LOW PYRUVATE CARBOXYLASE, ATP CITRATE LYASE, AND PYRUVATE CARBOXYLATION AND HIGH GLUCOSE-STIMULATED ACETOACETATE IN HUMAN PANCREATIC ISLETS

Anaplerosis, the net synthesis in mitochondria of citric acid cycle intermediates, and cataplerosis, their export to the cytosol, have been shown to be important for insulin secretion in rodent beta cells. However, human islets may be different. We observed that the enzyme activity, protein level, a...

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Bibliografische gegevens
Hoofdauteurs: MacDonald, Michael J., Longacre, Melissa J., Stoker, Scott W., Kendrick, Mindy, Thonpho, Ansaya, Brown, Laura J., Hasan, Noaman M., Jitrapakdee, Sarawut, Fukao, Toshiyuki, Hanson, Matthew S., Fernandez, Luis A., Odorico, Jon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2011
Onderwerpen:
Molecular Bases of Disease
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099655/
https://ncbi.nlm.nih.gov/pubmed/21454710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241182
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