Differences between Human and Rodent Pancreatic Islets: LOW PYRUVATE CARBOXYLASE, ATP CITRATE LYASE, AND PYRUVATE CARBOXYLATION AND HIGH GLUCOSE-STIMULATED ACETOACETATE IN HUMAN PANCREATIC ISLETS

Anaplerosis, the net synthesis in mitochondria of citric acid cycle intermediates, and cataplerosis, their export to the cytosol, have been shown to be important for insulin secretion in rodent beta cells. However, human islets may be different. We observed that the enzyme activity, protein level, a...

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Hauptverfasser: MacDonald, Michael J., Longacre, Melissa J., Stoker, Scott W., Kendrick, Mindy, Thonpho, Ansaya, Brown, Laura J., Hasan, Noaman M., Jitrapakdee, Sarawut, Fukao, Toshiyuki, Hanson, Matthew S., Fernandez, Luis A., Odorico, Jon
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2011
Schlagworte:
Molecular Bases of Disease
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099655/
https://ncbi.nlm.nih.gov/pubmed/21454710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.241182
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