Knockdown of ATP citrate lyase in pancreatic beta cells does not inhibit insulin secretion or glucose flux and implicates the acetoacetate pathway in insulin secretion

OBJECTIVE: Glucose-stimulated insulin secretion in pancreatic beta cells requires metabolic signals including the generation of glucose-derived short chain acyl-CoAs in the cytosol from mitochondrially-derived metabolites. One concept of insulin secretion is that ATP citrate lyase generates short ch...

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發表在:Mol Metab
Main Authors: El Azzouny, Mahmoud, Longacre, Melissa J., Ansari, Israr-ul H., Kennedy, Robert T., Burant, Charles F., MacDonald, Michael J.
格式: Artigo
語言:Inglês
出版: Elsevier 2016
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5034614/
https://ncbi.nlm.nih.gov/pubmed/27689010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.07.011
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