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ATP citrate lyase knockdown impacts cancer stem cells in vitro

ATP citrate lyase (ACL) knockdown (KD) causes tumor suppression and induces differentiation. We have previously reported that ACL KD reverses epithelial–mesenchymal transition (EMT) in lung cancer cells. Because EMT is often associated with processes that induce stemness, we hypothesized that ACL KD...

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Autori principali: Hanai, J-i, Doro, N, Seth, P, Sukhatme, V P
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3702307/
https://ncbi.nlm.nih.gov/pubmed/23807225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.215
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