Anthracycline-containing chemotherapy causes long-term impairment of mitochondrial respiration and increased reactive oxygen species release in skeletal muscle

Anticancer treatments for childhood acute lymphoblastic leukaemia (ALL) are highly effective but are now implicated in causing impaired muscle function in long-term survivors. However, no comprehensive assessment of skeletal muscle mitochondrial functions in long-term survivors has been performed an...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Gouspillou, Gilles, Scheede-Bergdahl, Celena, Spendiff, Sally, Vuda, Madhusudanarao, Meehan, Brian, Mlynarski, Heather, Archer-Lahlou, Elodie, Sgarioto, Nicolas, Purves-Smith, Fennigje M., Konokhova, Yana, Rak, Janusz, Chevalier, Stéphanie, Taivassalo, Tanja, Hepple, Russell T., Jagoe, R. Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346812/
https://ncbi.nlm.nih.gov/pubmed/25732599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08717
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