Failed upregulation of TFAM protein and mitochondrial DNA in oxidatively deficient fibers of chronic obstructive pulmonary disease locomotor muscle

BACKGROUND: Low mitochondrial content and oxidative capacity are well-established features of locomotor muscle dysfunction, a prevalent and debilitating systemic occurrence in patients with chronic obstructive pulmonary disease (COPD). Although the exact cause is not firmly established, physical ina...

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Pubblicato in:Skelet Muscle
Autori principali: Konokhova, Yana, Spendiff, Sally, Jagoe, R. Thomas, Aare, Sudhakar, Kapchinsky, Sophia, MacMillan, Norah J., Rozakis, Paul, Picard, Martin, Aubertin-Leheudre, Mylène, Pion, Charlotte H., Bourbeau, Jean, Hepple, Russell T., Taivassalo, Tanja
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2016
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4758107/
https://ncbi.nlm.nih.gov/pubmed/26893822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13395-016-0083-9
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