Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians

KEY POINTS: Mitochondria are frequently implicated in the ageing of skeletal muscle, although the role of denervation in modulating mitochondrial function in ageing muscle is unknown. We show that increased sensitivity to apoptosis initiation occurs prior to evidence of persistent denervation and is...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Spendiff, Sally, Vuda, Madhusudanarao, Gouspillou, Gilles, Aare, Sudhakar, Perez, Anna, Morais, José A., Jagoe, Robert T., Filion, Marie‐Eve, Glicksman, Robin, Kapchinsky, Sophia, MacMillan, Norah J., Pion, Charlotte H., Aubertin‐Leheudre, Mylène, Hettwer, Stefan, Correa, José A., Taivassalo, Tanja, Hepple, Russell T.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Muscle
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157074/
https://ncbi.nlm.nih.gov/pubmed/27619626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272487
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