Denervation drives mitochondrial dysfunction in skeletal muscle of octogenarians

KEY POINTS: Mitochondria are frequently implicated in the ageing of skeletal muscle, although the role of denervation in modulating mitochondrial function in ageing muscle is unknown. We show that increased sensitivity to apoptosis initiation occurs prior to evidence of persistent denervation and is...

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Опубликовано в: :J Physiol
Главные авторы: Spendiff, Sally, Vuda, Madhusudanarao, Gouspillou, Gilles, Aare, Sudhakar, Perez, Anna, Morais, José A., Jagoe, Robert T., Filion, Marie‐Eve, Glicksman, Robin, Kapchinsky, Sophia, MacMillan, Norah J., Pion, Charlotte H., Aubertin‐Leheudre, Mylène, Hettwer, Stefan, Correa, José A., Taivassalo, Tanja, Hepple, Russell T.
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2016
Предметы:
Muscle
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5157074/
https://ncbi.nlm.nih.gov/pubmed/27619626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP272487
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