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Increased 4-hydroxynonenal protein adducts in male GSTA4–4/PPAR-α double knockout mice enhance injury during early stages of alcoholic liver disease

To test the significance of lipid peroxidation in the development of alcoholic liver injury, an ethanol (EtOH) liquid diet was fed to male 129/SvJ mice (wild-type, WT) and glutathione S-transferase A4–4-null (GSTA4−/−) mice for 40 days. GSTA4−/− mice were crossed with peroxisome proliferator-activat...

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Pubblicato in:Am J Physiol Gastrointest Liver Physiol
Autori principali: Ronis, Martin J. J., Mercer, Kelly E., Gannon, Brenda, Engi, Bridgette, Zimniak, Piotr, Shearn, Colin T., Orlicky, David J., Albano, Emanuele, Badger, Thomas M., Petersen, Dennis R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346750/
https://ncbi.nlm.nih.gov/pubmed/25501545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00154.2014
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