Increased 4-hydroxynonenal protein adducts in male GSTA4–4/PPAR-α double knockout mice enhance injury during early stages of alcoholic liver disease

To test the significance of lipid peroxidation in the development of alcoholic liver injury, an ethanol (EtOH) liquid diet was fed to male 129/SvJ mice (wild-type, WT) and glutathione S-transferase A4–4-null (GSTA4−/−) mice for 40 days. GSTA4−/− mice were crossed with peroxisome proliferator-activat...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Ronis, Martin J. J., Mercer, Kelly E., Gannon, Brenda, Engi, Bridgette, Zimniak, Piotr, Shearn, Colin T., Orlicky, David J., Albano, Emanuele, Badger, Thomas M., Petersen, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2014
Assuntos:
Inflammation/Immunity/Mediators
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346750/
https://ncbi.nlm.nih.gov/pubmed/25501545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00154.2014
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