Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice

Chronic alcohol consumption induces hepatic oxidative stress resulting in production of highly reactive electrophilic α/β-unsaturated aldehydes that have the potential to modify proteins. A primary mechanism of reactive aldehyde detoxification by hepatocytes is through GSTA4-driven enzymatic conjuga...

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Detalhes bibliográficos
Publicado no:Redox Biol
Main Authors: Shearn, Colin T., Fritz, Kristofer S., Shearn, Alisabeth H., Saba, Laura M., Mercer, Kelly E., Engi, Bridgette, Galligan, James J., Zimniak, Piotr, Orlicky, David J., Ronis, Martin J., Petersen, Dennis R.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683459/
https://ncbi.nlm.nih.gov/pubmed/26654979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.11.013
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