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Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice

Chronic alcohol consumption induces hepatic oxidative stress resulting in production of highly reactive electrophilic α/β-unsaturated aldehydes that have the potential to modify proteins. A primary mechanism of reactive aldehyde detoxification by hepatocytes is through GSTA4-driven enzymatic conjuga...

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發表在:Redox Biol
Main Authors: Shearn, Colin T., Fritz, Kristofer S., Shearn, Alisabeth H., Saba, Laura M., Mercer, Kelly E., Engi, Bridgette, Galligan, James J., Zimniak, Piotr, Orlicky, David J., Ronis, Martin J., Petersen, Dennis R.
格式: Artigo
語言:Inglês
出版: Elsevier 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4683459/
https://ncbi.nlm.nih.gov/pubmed/26654979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2015.11.013
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