RIPK3 promotes cell death and NLRP3 inflammasome activation in the absence of MLKL

RIPK3 and its substrate MLKL are essential for necroptosis, a lytic cell death proposed to cause inflammation via the release of intracellular molecules. Whether and how RIPK3 might drive inflammation in a manner independent of MLKL and cell lysis remains unclear. Here we show that following LPS tre...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Lawlor, Kate E., Khan, Nufail, Mildenhall, Alison, Gerlic, Motti, Croker, Ben A., D’Cruz, Akshay A., Hall, Cathrine, Kaur Spall, Sukhdeep, Anderton, Holly, Masters, Seth L., Rashidi, Maryam, Wicks, Ian P., Alexander, Warren S., Mitsuuchi, Yasuhiro, Benetatos, Christopher A., Condon, Stephen M., Wong, W. Wei-Lynn, Silke, John, Vaux, David L., Vince, James E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Pub. Group 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346630/
https://ncbi.nlm.nih.gov/pubmed/25693118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7282
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