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TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1
Ligation of tumor necrosis factor receptor 1 (TNFR1) can cause cell death by caspase 8 or receptor-interacting protein kinase 1 (RIPK1)- and RIPK3-dependent mechanisms. It has been assumed that because RIPK1 bears a death domain (DD), but RIPK3 does not, RIPK1 is necessary for recruitment of RIPK3 i...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Publishing Group
2013
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3563989/ https://ncbi.nlm.nih.gov/pubmed/23328672 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.201 |
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