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TNF can activate RIPK3 and cause programmed necrosis in the absence of RIPK1

Ligation of tumor necrosis factor receptor 1 (TNFR1) can cause cell death by caspase 8 or receptor-interacting protein kinase 1 (RIPK1)- and RIPK3-dependent mechanisms. It has been assumed that because RIPK1 bears a death domain (DD), but RIPK3 does not, RIPK1 is necessary for recruitment of RIPK3 i...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Moujalled, D M, Cook, W D, Okamoto, T, Murphy, J, Lawlor, K E, Vince, J E, Vaux, D L
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2013
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3563989/
https://ncbi.nlm.nih.gov/pubmed/23328672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.201
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