Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin 1 receptor (IL-1R)-dependent caspase-1-independent inflammatory disease. Conditional deletion of Ptpn6 in neutrophils (Ptpn6(ΔPMN)) is sufficient to initiate IL-1R-dependent cutaneous inflammatory disease, but th...

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Bibliografske podrobnosti
izdano v:Nat Immunol
Main Authors: Speir, Mary, Nowell, Cameron J., Chen, Alyce A., O’Donnell, Joanne A., Shamie, Isaac S., Lakin, Paul R., D’Cruz, Akshay A., Braun, Roman O., Babon, Jeff J., Lewis, Rowena S., Bliss-Moreau, Meghan, Shlomovitz, Inbar, Wang, Shu, Cengia, Louise H., Stoica, Anca I., Hakem, Razq, Kelliher, Michelle A., O’Reilly, Lorraine A., Patsiouras, Heather, Lawlor, Kate E, Weller, Edie, Lewis, Nathan E., Roberts, Andrew W., Gerlic, Motti, Croker, Ben A.
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923591/
https://ncbi.nlm.nih.gov/pubmed/31819256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0550-7
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