Ptpn6 inhibits caspase-8- and Ripk3/Mlkl-dependent inflammation

Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin 1 receptor (IL-1R)-dependent caspase-1-independent inflammatory disease. Conditional deletion of Ptpn6 in neutrophils (Ptpn6(ΔPMN)) is sufficient to initiate IL-1R-dependent cutaneous inflammatory disease, but th...

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Publicado no:Nat Immunol
Main Authors: Speir, Mary, Nowell, Cameron J., Chen, Alyce A., O’Donnell, Joanne A., Shamie, Isaac S., Lakin, Paul R., D’Cruz, Akshay A., Braun, Roman O., Babon, Jeff J., Lewis, Rowena S., Bliss-Moreau, Meghan, Shlomovitz, Inbar, Wang, Shu, Cengia, Louise H., Stoica, Anca I., Hakem, Razq, Kelliher, Michelle A., O’Reilly, Lorraine A., Patsiouras, Heather, Lawlor, Kate E, Weller, Edie, Lewis, Nathan E., Roberts, Andrew W., Gerlic, Motti, Croker, Ben A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6923591/
https://ncbi.nlm.nih.gov/pubmed/31819256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-019-0550-7
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