The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

Neutrophil extracellular trap (NET) formation can generate short-term, functional anucleate cytoplasts and trigger loss of cell viability. We demonstrated that the necroptotic cell death effector mixed lineage kinase domain–like (MLKL) translocated from the cytoplasm to the plasma membrane and stimu...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Signal
Egile Nagusiak: D’Cruz, Akshay A., Speir, Mary, Bliss-Moreau, Meghan, Dietrich, Sylvia, Wang, Shu, Chen, Alyce A., Gavillet, Mathilde, Al-Obeidi, Arshed, Lawlor, Kate E., Vince, James E., Kelliher, Michelle A., Hakem, Razq, Pasparakis, Manolis, Williams, David A., Ericsson, Maria, Croker, Ben A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301070/
https://ncbi.nlm.nih.gov/pubmed/30181240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao1716
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