The pseudokinase MLKL activates PAD4-dependent NET formation in necroptotic neutrophils

Neutrophil extracellular trap (NET) formation can generate short-term, functional anucleate cytoplasts and trigger loss of cell viability. We demonstrated that the necroptotic cell death effector mixed lineage kinase domain–like (MLKL) translocated from the cytoplasm to the plasma membrane and stimu...

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Bibliographic Details
Published in:Sci Signal
Main Authors: D’Cruz, Akshay A., Speir, Mary, Bliss-Moreau, Meghan, Dietrich, Sylvia, Wang, Shu, Chen, Alyce A., Gavillet, Mathilde, Al-Obeidi, Arshed, Lawlor, Kate E., Vince, James E., Kelliher, Michelle A., Hakem, Razq, Pasparakis, Manolis, Williams, David A., Ericsson, Maria, Croker, Ben A.
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6301070/
https://ncbi.nlm.nih.gov/pubmed/30181240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aao1716
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