The pseudokinase MLKL and the kinase RIPK3 have distinct roles in autoimmune disease caused by loss of death receptor induced apoptosis

The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficiency rescued the embryonic lethality caused by loss...

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Detalhes bibliográficos
Publicado no:Immunity
Main Authors: Alvarez-Diaz, Silvia, Dillon, Christopher P., Lalaoui, Najoua, Tanzer, Maria C., Rodriguez, Diego A., Lin, Ann, Lebois, Marion, Hakem, Razq, Josefsson, Emma C., O’Reilly, Lorraine A, Silke, John, Alexander, Warren S, Green, Douglas R., Strasser, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5040700/
https://ncbi.nlm.nih.gov/pubmed/27523270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2016.07.016
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