Non-transcriptional role of Hif-1α in activation of γ-secretase and Notch signaling in breast cancer

γ-Secretase is composed of four proteins that are obligatory for protease activity: Presenilin, Nicastrin, Aph1 and Pen-2. Despite the progress towards understanding the function of these individual subunits, there is no information available pertaining to the modulation of γ-secretase in response t...

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Pubblicato in:Cell Rep
Autori principali: Villa, Jennifer C., Chiu, Danica, Brandes, Alissa H., Escorcia, Freddy E., Villa, Carlos H., Maguire, William F., Hu, Cheng-Jun, de Stanchina, Elisa, Simon, M. Celeste, Sisodia, Sangram S., Scheinberg, David A., Li, Yue-Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346175/
https://ncbi.nlm.nih.gov/pubmed/25131208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.07.028
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