Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

Sirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no deacetylase activity, and a robust catalytic activity for SIRT4 has been elusive. Here, we establish SIRT4 as a cellular...

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Bibliographische Detailangaben
Veröffentlicht in:Cell
Hauptverfasser: Mathias, Rommel A., Greco, Todd M., Oberstein, Adam, Budayeva, Hanna G., Chakrabarti, Rumela, Rowland, Elizabeth A., Kang, Yibin, Shenk, Thomas, Cristea, Ileana M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344121/
https://ncbi.nlm.nih.gov/pubmed/25525879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.046
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