Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

Sirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no deacetylase activity, and a robust catalytic activity for SIRT4 has been elusive. Here, we establish SIRT4 as a cellular...

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Detalhes bibliográficos
Publicado no:Cell
Main Authors: Mathias, Rommel A., Greco, Todd M., Oberstein, Adam, Budayeva, Hanna G., Chakrabarti, Rumela, Rowland, Elizabeth A., Kang, Yibin, Shenk, Thomas, Cristea, Ileana M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344121/
https://ncbi.nlm.nih.gov/pubmed/25525879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.046
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