Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity

Sirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no deacetylase activity, and a robust catalytic activity for SIRT4 has been elusive. Here, we establish SIRT4 as a cellular...

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Udgivet i:Cell
Main Authors: Mathias, Rommel A., Greco, Todd M., Oberstein, Adam, Budayeva, Hanna G., Chakrabarti, Rumela, Rowland, Elizabeth A., Kang, Yibin, Shenk, Thomas, Cristea, Ileana M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344121/
https://ncbi.nlm.nih.gov/pubmed/25525879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.11.046
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