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Targeted Delivery of Antisense Oligodeoxynucleotide by Transferrin Conjugated pH-Sensitive Lipopolyplex Nanoparticles: A Novel Oligonucleotide –Based Therapeutic Strategy in Acute Myeloid Leukemia

Therapeutic use of oligodeoxynucleotides (ODNs) that hybridize to and downregulate target messenger RNAs (mRNAs) encoding proteins that contribute to malignant transformation has a sound rationale, but has had an overall limited clinical success in cancer due to insufficient intracellular delivery....

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Mol Pharm
Κύριοι συγγραφείς: Jin, Yan, Liu, Shujun, Yu, Bo, Golan, Sharon, Koh, Chee-Guan, Yang, Jintao, Huynh, Lenguyen, Yang, Xiaojuan, Pang, Jiuxia, Muthusamy, Natarajan, Chan, Kenneth K., Byrd, John C., Talmon, Yeshayahu, Lee, L. James, Lee, Robert J., Marcucci, Guido
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: 2010
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4342499/
https://ncbi.nlm.nih.gov/pubmed/19852511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp900205r
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