Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing

A multi-inlet microfluidic hydrodynamic focusing (MF) system to prepare lipopolyplex (LP) containing Bcl-2 antisense deoxyoligonucleotide (ODN) was developed and evaluated. The lipopolyplex nanoparticles consist of ODN:protamine:lipids (1:0.3:12.5 wt/wt ratio) and the lipids included DC-Chol:egg PC:...

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Detalhes bibliográficos
Publicado no:J Control Release
Main Authors: Koh, Chee Guan, Zhang, Xulang, Liu, Shujun, Golan, Sharon, Yu, Bo, Yang, Xiaojuan, Guan, Jingjiao, Jin, Yan, Talmon, Yeshayahu, Muthusamy, Natarajan, Chan, Kenneth K, Byrd, John C., Lee, Robert J., Marcucci, Guido, Lee, L. James
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289903/
https://ncbi.nlm.nih.gov/pubmed/19716852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2009.08.019
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