Delivery of antisense oligodeoxyribonucleotide lipopolyplex nanoparticles assembled by microfluidic hydrodynamic focusing

A multi-inlet microfluidic hydrodynamic focusing (MF) system to prepare lipopolyplex (LP) containing Bcl-2 antisense deoxyoligonucleotide (ODN) was developed and evaluated. The lipopolyplex nanoparticles consist of ODN:protamine:lipids (1:0.3:12.5 wt/wt ratio) and the lipids included DC-Chol:egg PC:...

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Vydáno v:J Control Release
Hlavní autoři: Koh, Chee Guan, Zhang, Xulang, Liu, Shujun, Golan, Sharon, Yu, Bo, Yang, Xiaojuan, Guan, Jingjiao, Jin, Yan, Talmon, Yeshayahu, Muthusamy, Natarajan, Chan, Kenneth K, Byrd, John C., Lee, Robert J., Marcucci, Guido, Lee, L. James
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4289903/
https://ncbi.nlm.nih.gov/pubmed/19716852
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2009.08.019
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