Targeted Delivery of microRNA-29b by Transferrin Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia

PURPOSE: miR-29b directly or indirectly targets genes involved in acute myeloid leukemia (AML) i.e., DNMTs, CDK6, SP1, KIT and FLT3. Higher miR-29b pretreatment expression is associated with improved response to decitabine and better outcome in AML. Thus designing a strategy to increase miR-29b leve...

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Bibliografiske detaljer
Main Authors: Huang, Xiaomeng, Schwind, Sebastian, Yu, Bo, Santhanam, Ramasamy, Wang, Hongyan, Hoellerbauer, Pia, Mims, Alice, Klisovic, Rebecca, Walker, Alison R., Chan, Kenneth K., Blum, William, Perrotti, Danilo, Byrd, John C., Bloomfield, Clara D., Caligiuri, Michael A., Lee, Robert J., Garzon, Ramiro, Muthusamy, Natarajan, Lee, L. James, Marcucci, Guido
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3644023/
https://ncbi.nlm.nih.gov/pubmed/23493348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3191
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