ATM-Mediated Stabilization of hMutL DNA Mismatch Repair Proteins Augments p53 Activation during DNA Damage

Human DNA mismatch repair (MMR) proteins correct DNA errors and regulate cellular response to DNA damage by signaling apoptosis. Mutations of MMR genes result in genomic instability and cancer development. Nonetheless, how MMR proteins are regulated has not yet been determined. While hMLH1, hPMS2, a...

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Bibliographische Detailangaben
Hauptverfasser: Luo, Yuhong, Lin, Fang-Tsyr, Lin, Weei-Chin
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
DNA Dynamics and Chromosome Structure
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC434232/
https://ncbi.nlm.nih.gov/pubmed/15226443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.14.6430-6444.2004
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