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Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation

Previous work has established a role for p53 in triggering apoptosis in response to DNA damage; p53 also induces apoptosis in response to deregulation of the Rb cell cycle pathway. The latter event is consistent with a role for the Rb-regulated E2F1 protein as a specific inducer of apoptosis and p53...

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Detalhes bibliográficos
Main Authors: Lin, Weei-Chin, Lin, Fang-Tsyr, Nevins, Joseph R.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC312742/
https://ncbi.nlm.nih.gov/pubmed/11459832
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