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Parkinsonism-associated Protein DJ-1/Park7 Is a Major Protein Deglycase That Repairs Methylglyoxal- and Glyoxal-glycated Cysteine, Arginine, and Lysine Residues

Glycation is an inevitable nonenzymatic covalent reaction between proteins and endogenous reducing sugars or dicarbonyls (methylglyoxal, glyoxal) that results in protein inactivation. DJ-1 was reported to be a multifunctional oxidative stress response protein with poorly defined function. Here, we s...

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Podrobná bibliografie
Vydáno v:J Biol Chem
Hlavní autoři: Richarme, Gilbert, Mihoub, Mouadh, Dairou, Julien, Bui, Linh Chi, Leger, Thibaut, Lamouri, Aazdine
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4340429/
https://ncbi.nlm.nih.gov/pubmed/25416785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.597815
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