The apparent deglycase activity of DJ-1 results from the conversion of free methylglyoxal present in fast equilibrium with hemithioacetals and hemiaminals

Loss-of-function mutations in the gene encoding human protein DJ-1 cause early onset of Parkinson's disease, suggesting that DJ-1 protects dopaminergic neurons. The molecular mechanisms underlying this neuroprotection are unclear; however, DJ-1 has been suggested to be a GSH-independent glyoxal...

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Vydáno v:J Biol Chem
Hlavní autoři: Andreeva, Anna, Bekkhozhin, Zhanibek, Omertassova, Nuriza, Baizhumanov, Timur, Yeltay, Gaziza, Akhmetali, Mels, Toibazar, Daulet, Utepbergenov, Darkhan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Enzymology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901308/
https://ncbi.nlm.nih.gov/pubmed/31653696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.011237
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