Deglycase-activity oriented screening to identify DJ-1 inhibitors

The oncoprotein and Parkinson's disease-associated enzyme DJ-1/PARK7 has emerged as a promiscuous deglycase that can remove methylglyoxal-induced glycation adducts from both proteins and nucleotides. However, dissecting its structural and enzymatic functions remains a challenge due to the lack...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:RSC Med Chem
Prif Awduron: Maksimovic, Igor, Finkin-Groner, Efrat, Fukase, Yoshiyuki, Zheng, Qingfei, Sun, Shan, Michino, Mayako, Huggins, David J., Myers, Robert W., David, Yael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: RSC 2021
Pynciau:
Chemistry
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC8292988/
https://ncbi.nlm.nih.gov/pubmed/34355187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d1md00062d
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