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Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification
Methylglyoxal (MG) is a reactive metabolite that forms adducts on cysteine, lysine and arginine residues of proteins, thereby affecting their function. Methylglyoxal is detoxified by the Glyoxalase system, consisting of two enzymes, Glo1 and Glo2, that act sequentially to convert MG into d-lactate....
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| Pubblicato in: | J Biol Chem |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5241742/ https://ncbi.nlm.nih.gov/pubmed/27903648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.743823 |
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