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Evidence Against a Role for the Parkinsonism-associated Protein DJ-1 in Methylglyoxal Detoxification
Methylglyoxal (MG) is a reactive metabolite that forms adducts on cysteine, lysine and arginine residues of proteins, thereby affecting their function. Methylglyoxal is detoxified by the Glyoxalase system, consisting of two enzymes, Glo1 and Glo2, that act sequentially to convert MG into d-lactate....
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| Publicado no: | J Biol Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5241742/ https://ncbi.nlm.nih.gov/pubmed/27903648 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.743823 |
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