PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

XRCC4 and XLF are two structurally-related proteins that function in DNA double-strand break (DSB) repair. Here, we identify human PAXX (PAralog of XRCC4 and XLF; also called C9orf142) as a new XRCC4-superfamily member, and show that its crystal structure resembles that of XRCC4. PAXX interacts dire...

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Veröffentlicht in:Science
Hauptverfasser: Ochi, Takashi, Blackford, Andrew N., Coates, Julia, Jhujh, Satpal, Mehmood, Shahid, Tamura, Naoka, Travers, Jon, Wu, Qian, Draviam, Viji M., Robinson, Carol V., Blundell, Tom L., Jackson, Stephen P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338599/
https://ncbi.nlm.nih.gov/pubmed/25574025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1261971
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