Synthetic lethality between PAXX and XLF in mammalian development

PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf(−/−) mice, Paxx(−/−) mice are viable, grow normally, and are fertile but show mild radiosensitivity. Strikingly, whi...

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Bibliografische gegevens
Gepubliceerd in:Genes Dev
Hoofdauteurs: Balmus, Gabriel, Barros, Ana C., Wijnhoven, Paul W.G., Lescale, Chloé, Hasse, Hélène Lenden, Boroviak, Katharina, le Sage, Carlos, Doe, Brendan, Speak, Anneliese O., Galli, Antonella, Jacobsen, Matt, Deriano, Ludovic, Adams, David J., Blackford, Andrew N., Jackson, Stephen P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cold Spring Harbor Laboratory Press 2016
Onderwerpen:
Research Communication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088564/
https://ncbi.nlm.nih.gov/pubmed/27798842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.290510.116
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