Synthetic lethality between PAXX and XLF in mammalian development

PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf(−/−) mice, Paxx(−/−) mice are viable, grow normally, and are fertile but show mild radiosensitivity. Strikingly, whi...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Balmus, Gabriel, Barros, Ana C., Wijnhoven, Paul W.G., Lescale, Chloé, Hasse, Hélène Lenden, Boroviak, Katharina, le Sage, Carlos, Doe, Brendan, Speak, Anneliese O., Galli, Antonella, Jacobsen, Matt, Deriano, Ludovic, Adams, David J., Blackford, Andrew N., Jackson, Stephen P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2016
Assuntos:
Research Communication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088564/
https://ncbi.nlm.nih.gov/pubmed/27798842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.290510.116
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