Synthetic lethality between PAXX and XLF in mammalian development

PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf(−/−) mice, Paxx(−/−) mice are viable, grow normally, and are fertile but show mild radiosensitivity. Strikingly, whi...

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Bibliografiska uppgifter
I publikationen:Genes Dev
Huvudupphovsmän: Balmus, Gabriel, Barros, Ana C., Wijnhoven, Paul W.G., Lescale, Chloé, Hasse, Hélène Lenden, Boroviak, Katharina, le Sage, Carlos, Doe, Brendan, Speak, Anneliese O., Galli, Antonella, Jacobsen, Matt, Deriano, Ludovic, Adams, David J., Blackford, Andrew N., Jackson, Stephen P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cold Spring Harbor Laboratory Press 2016
Ämnen:
Research Communication
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088564/
https://ncbi.nlm.nih.gov/pubmed/27798842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.290510.116
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