Synthetic lethality between PAXX and XLF in mammalian development

PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf(−/−) mice, Paxx(−/−) mice are viable, grow normally, and are fertile but show mild radiosensitivity. Strikingly, whi...

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Veröffentlicht in:Genes Dev
Hauptverfasser: Balmus, Gabriel, Barros, Ana C., Wijnhoven, Paul W.G., Lescale, Chloé, Hasse, Hélène Lenden, Boroviak, Katharina, le Sage, Carlos, Doe, Brendan, Speak, Anneliese O., Galli, Antonella, Jacobsen, Matt, Deriano, Ludovic, Adams, David J., Blackford, Andrew N., Jackson, Stephen P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2016
Schlagworte:
Research Communication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5088564/
https://ncbi.nlm.nih.gov/pubmed/27798842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.290510.116
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