Accurate Measurement of 5-Methylcytosine and 5-Hydroxymethylcytosine in Human Cerebellum DNA by Oxidative Bisulfite on an Array (OxBS-Array)

The Infinium 450K Methylation array is an established tool for measuring methylation. However, the bisulfite (BS) reaction commonly used with the 450K array cannot distinguish between 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC). The oxidative-bisulfite assay disambiguates 5mC and 5hmC....

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Bibliographic Details
Published in:PLoS One
Main Authors: Field, Sarah F., Beraldi, Dario, Bachman, Martin, Stewart, Sabrina K., Beck, Stephan, Balasubramanian, Shankar
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338296/
https://ncbi.nlm.nih.gov/pubmed/25706862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118202
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