A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

AIMS: β-amyloid (Aβ) plaques are a key feature of Alzheimer’s disease pathology but correlate poorly with dementia. They are associated with astrocytes which may modulate the effect of Aβ-deposition on the neuropil. This study characterised the astrocyte response to Aβ plaque subtypes, and investiga...

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Bibliographic Details
Published in:PLoS One
Main Authors: Mathur, Ryan, Ince, Paul G., Minett, Thais, Garwood, Claire J., Shaw, Pamela J., Matthews, Fiona E., Brayne, Carol, Simpson, Julie E., Wharton, Stephen B.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4338046/
https://ncbi.nlm.nih.gov/pubmed/25707004
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0118463
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