A Reduced Astrocyte Response to β-Amyloid Plaques in the Ageing Brain Associates with Cognitive Impairment

Eitemau Tebyg

• The nuclear retention of transcription factor FOXO3a correlates with a DNA damage response and increased glutamine synthetase expression by astrocytes suggesting a neuroprotective role in the ageing brain
  gan: Fluteau, Adeline, et al.
  Cyhoeddwyd: (2015)
• A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort
  gan: Simpson, Julie E., et al.
  Cyhoeddwyd: (2015)
• Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer‐type pathology
  gan: Simpson, Julie E., et al.
  Cyhoeddwyd: (2015)
• Epidemiological pathology of Tau in the ageing brain: application of staging for neuropil threads (BrainNet Europe protocol) to the MRC cognitive function and ageing brain study
  gan: Wharton, Stephen B., et al.
  Cyhoeddwyd: (2016)
• Dementia prediction for people with stroke in populations: is mild cognitive impairment a useful concept?
  gan: Stephan, Blossom C. M., et al.
  Cyhoeddwyd: (2015)