Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number

BACKGROUND: The borders of Thailand harbour the world’s most multidrug resistant Plasmodium falciparum parasites. In 1984 mefloquine was introduced as treatment for uncomplicated falciparum malaria, but substantial resistance developed within 6 years. A combination of artesunate with mefloquine now...

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Bibliografiske detaljer
Udgivet i:	Lancet
Main Authors:	Price, Ric N, Uhlemann, Anne-Catrin, Brockman, Alan, McGready, Rose, Ashley, Elizabeth, Phaipun, Lucy, Patel, Rina, Laing, Kenneth, Looareesuwan, Sornchai, White, Nicholas J, Nosten, François, Krishna, Sanjeev
Format:	Artigo
Sprog:	Inglês
Udgivet:	2004
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4337987/ https://ncbi.nlm.nih.gov/pubmed/15288742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(04)16767-6
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Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number

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