Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains

Previous reports have shown that individual neurons of the brain can display somatic genomic mosaicism of unknown function. In this study, we report altered genomic mosaicism in single, sporadic Alzheimer's disease (AD) neurons characterized by increases in DNA content and amyloid precursor pro...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Bushman, Diane M, Kaeser, Gwendolyn E, Siddoway, Benjamin, Westra, Jurgen W, Rivera, Richard R, Rehen, Stevens K, Yung, Yun C, Chun, Jerold
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Neuroscience
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4337608/
https://ncbi.nlm.nih.gov/pubmed/25650802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05116
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